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Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer: a multicentre randomised controlled trial.
- Source :
- Supportive Care in Cancer; Jul2020, Vol. 28 Issue 7, p3331-3342, 12p
- Publication Year :
- 2020
-
Abstract
- <bold>Purpose: </bold>Radiotherapy to the prostate gland and pelvic lymph nodes may cause acute and late bowel symptoms and diminish quality of life. The aim was to study the effects of a nutrition intervention on bowel symptoms and health-related quality of life, compared with standard care.<bold>Methods: </bold>Patients were randomised to a nutrition intervention (n = 92) aiming to replace insoluble fibres with soluble and reduce intake of lactose, or a standard care group (n = 88) who were recommended to maintain their habitual diet. Bowel symptoms, health-related quality of life and intake of fibre and lactose-containing foods were assessed up to 24 months after radiotherapy completion. Multiple linear regression was used to analyse the effects of the nutrition intervention on bowel symptoms during the acute (up to 2 months post radiotherapy) and the late (7 to 24 months post radiotherapy) phase.<bold>Results: </bold>Most symptoms and functioning worsened during the acute phase, and improved during the late phase in both the intervention and standard care groups. The nutrition intervention was associated with less blood in stools (p = 0.047), flatulence (p = 0.014) and increased loss of appetite (p = 0.018) during the acute phase, and more bloated abdomen in the late phase (p = 0.029). However, these associations were clinically trivial or small.<bold>Conclusions: </bold>The effect of the nutrition intervention related to dietary fibre and lactose on bowel symptoms from pelvic RT was small and inconclusive, although some minor and transient improvements were observed. The results do not support routine nutrition intervention of this type to reduce adverse effects from pelvic radiotherapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- LACTOSE intolerance
QUALITY of life
PROSTATE cancer patients
NUTRITION
PROSTATE
APPETITE loss
MENTAL health
INFLAMMATORY bowel disease treatment
RESEARCH
INFLAMMATORY bowel diseases
TIME
RESEARCH methodology
NUTRITIONAL requirements
EVALUATION research
MEDICAL cooperation
COMPARATIVE studies
RANDOMIZED controlled trials
RESEARCH funding
PROSTATE tumors
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 09414355
- Volume :
- 28
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 143477005
- Full Text :
- https://doi.org/10.1007/s00520-019-05182-5