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Cervical Pathology Following HPV Vaccination in Greece: A 10-year He CPA Observational Cohort Study.
- Source :
- In Vivo; May/Jun2020, Vol. 34 Issue 3, p1445-1449, 5p
- Publication Year :
- 2020
-
Abstract
- Background: In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV vaccinated and unvaccinated women referred for colposcopy. Patients and Methods: This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for colposcopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected. Results: A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated. Conclusion: HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity. [ABSTRACT FROM AUTHOR]
- Subjects :
- HUMAN papillomavirus vaccines
CERVICAL cancer diagnosis
COLPOSCOPY
CYTOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 0258851X
- Volume :
- 34
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- In Vivo
- Publication Type :
- Academic Journal
- Accession number :
- 143143892
- Full Text :
- https://doi.org/10.21873/invivo.11927