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The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL).
- Source :
- Leukemia & Lymphoma; May2020, Vol. 61 Issue 5, p1133-1139, 7p
- Publication Year :
- 2020
-
Abstract
- We analyzed the prognostic impact of levels of free light chains (FLC) in 106 patients with DLBCL, selecting 61 patients with a monoclonal (M) protein in serum, and 45 patients without a M protein as an IPI-matched control group. Patients with a M protein had higher levels of FLC, but these were not of prognostic significance in this group. The presence of a M protein nullified associations of κ-FLC with several laboratory parameters indicating immune system activation observed in patients without a M protein. Patients without M protein and κ-FLC >50 mg/L had a significant inferior event-free survival (p =.004). The presence of M protein of an IgM type at diagnosis was a negative outcome predictor (p =.008), while a non-IgM M protein did not significantly impact on prognosis. In conclusion, the prognostic performance of the FLC assay is altered by the presence of a M protein. [ABSTRACT FROM AUTHOR]
- Subjects :
- B cells
GLOBULINS
BLOOD proteins
LYMPHOMAS
SECRETION
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 61
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 143138936
- Full Text :
- https://doi.org/10.1080/10428194.2019.1706731