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Breast Cancer Quality of Life and Health-state Utility at a Brazilian Reference Public Cancer Center.
- Source :
- Expert Review of Pharmacoeconomics & Outcomes Research; Apr2020, Vol. 20 Issue 2, p185-191, 7p
- Publication Year :
- 2020
-
Abstract
- Objectives: To evaluate health-related-quality-of-life and derive health-state-utility (HSU) from breast cancer patients, before and after routine therapy at a Brazilian reference public cancer center.Methods: In a prospective cohort study, a consecutive sample of outpatients newly diagnosed with breast cancer was submitted to two interviews (baseline, 6-month) to complete EQ-5D-3L/VAS and EORTC-QLQ-C30/BR23 questionnaires. Demographic and clinical information was reviewed from medical records.Results: For 196 patients, EQ-5D domains of pain/discomfort and anxiety/depression were mainly affected, but partially improved overtime, while mobility/usual activities/self-care worsened after therapy. EORTC-QLQ-C30/BR23 scales mostly affected were emotional functioning, insomnia, pain, sexual enjoyment and future self-health perspective at baseline, while financial difficulties, insomnia, fatigue and therapy side-effects at follow-up. Overtime mean scores were 71.4 (95%CI68.5-74.4) and 76.1 (95%CI73.3-78.8) for EQ-5D-VAS, and 0.712 (95%CI0.686-0.737) and 0.732 (95%CI0.707-0.757) for HSU. HSU was 0.689 (95%CI0.648-0.730) in stages III-IV, and 0.692 (95%CI0.652-0.731) under two/three chemotherapy regimens.Conclusion: In a context of impairments in emotional functioning, sexual enjoyment, symptoms burden, and poor future self-health perspective, breast cancer produced a mean HSU of 0.712. After routine care, there was a small improvement in quality of life, with lower HSU particularly in advanced disease and multiple chemotherapy regimens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14737167
- Volume :
- 20
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Expert Review of Pharmacoeconomics & Outcomes Research
- Publication Type :
- Academic Journal
- Accession number :
- 143114351
- Full Text :
- https://doi.org/10.1080/14737167.2019.1621752