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Functional marriage in plasma membrane: Critical cholesterol level-optimal protein activity.
- Source :
- British Journal of Pharmacology; Jun2020, Vol. 177 Issue 11, p2456-2465, 10p, 2 Diagrams, 1 Chart
- Publication Year :
- 2020
-
Abstract
- In physiology, homeostasis refers to the condition where a system exhibits an optimum functional level. In contrast, any variation from this optimum is considered as a dysfunctional or pathological state. In this review, we address the proposal that a critical cholesterol level in the plasma membrane is required for the proper functioning of transmembrane proteins. Thus, membrane cholesterol depletion or enrichment produces a loss or gain of direct cholesterol-protein interaction and/or changes in the physical properties of the plasma membrane, which affect the basal or optimum activity of transmembrane proteins. Whether or not this functional switching is a generalized mechanism exhibited for all transmembrane proteins, or if it works just for an exclusive group of them, is an open question and an attractive subject to explore at a basic, pharmacological and clinical level. [ABSTRACT FROM AUTHOR]
- Subjects :
- MEMBRANE proteins
CHOLESTEROL
PROTEINS
MARRIAGE
OPEN-ended questions
Subjects
Details
- Language :
- English
- ISSN :
- 00071188
- Volume :
- 177
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- British Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 143093388
- Full Text :
- https://doi.org/10.1111/bph.15027