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Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics.

Authors :
Sharifi-Rad, Mehdi
Lankatillake, Chintha
Dias, Daniel A.
Docea, Anca Oana
Mahomoodally, Mohamad Fawzi
Lobine, Devina
Chazot, Paul L.
Kurt, Begum
Boyunegmez Tumer, Tugba
Catarina Moreira, Ana
Sharopov, Farukh
Martorell, Miquel
Martins, Natália
Cho, William C.
Calina, Daniela
Sharifi-Rad, Javad
Source :
Journal of Clinical Medicine; Apr2020, Vol. 9 Issue 4, p1061, 1p
Publication Year :
2020

Abstract

Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
9
Issue :
4
Database :
Complementary Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
143079382
Full Text :
https://doi.org/10.3390/jcm9041061