Randomised trial of cord clamping at very preterm birth: outcomes at 2 years.

<bold>Objective: </bold>To report outcomes at 2 years corrected age for children of women recruited to a trial comparing alternative policies for timing of cord clamping and immediate neonatal care at very preterm birth.<bold>Design: </bold>Parallel group randomised (1:1) trial.<bold>Setting: </bold>Eight UK tertiary maternity units.<bold>Participants: </bold>Two hundred and seventy-six babies born to 261 women expected to have a live birth before 32+0 weeks' gestation.<bold>Interventions: </bold>Deferred cord clamping (≥2 min) and immediate neonatal care with cord intact or immediate (≤20 s) clamping and immediate neonatal care after clamping.<bold>Main Outcome Measure: </bold>Composite of death or adverse neurodevelopmental outcome at 2 years corrected age.<bold>Results: </bold>Six babies born after 35+6 weeks were excluded. At 2 years corrected age, outcome data were not available for a further 52 children, leaving 218 for analysis (115 deferred clamping, 103 immediate clamping). Overall, 24/115 (21%) children allocated deferred clamping died or had an adverse neurodevelopmental outcome compared with 35/103 (34%) allocated immediate clamping; risk ratio (RR) 0.61 (95% CI 0.39 to 0.96); risk difference (RD) -13% (95% CI -25% to -1%). Multiple imputation for missing data gave an RR 0.69 (95% CI 0.44 to 1.09) and RD -9% (95% CI -21% to 2%).<bold>Conclusions: </bold>Deferred clamping and immediate neonatal care with cord intact may reduce the risk of death or adverse neurodevelopmental outcome at 2 years of age for children born very premature. Confirmation in larger studies is needed to determine the real benefits and harms.<bold>Trial Registration Number: </bold>ISRCTN21456601. [ABSTRACT FROM AUTHOR]