Back to Search
Start Over
Rhodium(III)‐Catalyzed Asymmetric Access to Spirocycles through C−H Activation and Axial‐to‐Central Chirality Transfer.
- Source :
- Angewandte Chemie International Edition; 4/27/2020, Vol. 59 Issue 18, p7188-7192, 5p
- Publication Year :
- 2020
-
Abstract
- Axial‐to‐central chirality transfer is an important strategy to construct chiral centers, where the axially chiral reagents are mostly limited to atropomerically stable ones. Reported herein is a RhIII‐catalyzed enantioselective spiroannulative synthesis of nitrones. The coupling proceeds via C−H arylation to give an atropomerically metastable biaryl, followed by intramolecular dearomative trapping under oxidative conditions with high degree of chirality transfer. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHIRALITY
RHODIUM
CHIRAL centers
CLASS B metals
ARYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 142811051
- Full Text :
- https://doi.org/10.1002/anie.202000174