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Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-β-induced JNK activation.

Authors :
Karakashian, Alexander A.
Giltiay, Natalia V.
Smith, George M.
Nikolova-Karakashian, Mariana N.
Source :
FASEB Journal; Jun2004, Vol. 18 Issue 9, p968-970, 3p, 1 Black and White Photograph, 1 Diagram, 1 Graph
Publication Year :
2004

Abstract

Focuses on the findings of a study which examined the role of neutral plasma membrane sphingomyelinase-2 (NSMase-2) in signal transduction, particularly in interleukin-1β signaling. Molecular cloning and functional characterization of NSMase-2; Effects of NSMase-2 expression on interleukin-1β-induced JNK activation; Impact of NSMase-2 overexpression on the phosphorylation pattern of interleukin-1&beta receptor-associated kinase.

Details

Language :
English
ISSN :
08926638
Volume :
18
Issue :
9
Database :
Complementary Index
Journal :
FASEB Journal
Publication Type :
Academic Journal
Accession number :
14265659
Full Text :
https://doi.org/10.1096/fj.03-0875fje