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Stereoselective Thermal Addition of RP and/or SP‐Menthyl‐Deriving Secondary Phosphine Oxides to Active Alkynes, the Mechanism, Stereochemistry and Generation of P,C‐Chirogenic Bis‐Phosphine Derivatives.
Stereoselective Thermal Addition of RP and/or SP‐Menthyl‐Deriving Secondary Phosphine Oxides to Active Alkynes, the Mechanism, Stereochemistry and Generation of P,C‐Chirogenic Bis‐Phosphine Derivatives.
- Source :
- Asian Journal of Organic Chemistry; Apr2020, Vol. 9 Issue 4, p566-570, 5p
- Publication Year :
- 2020
-
Abstract
- The additions of RP‐1 or SP‐1 to alkynyl esters stereo selectively afforded bis‐phosphinylated derivatives having up to four C‐ and P‐chirogenic centers. The stereochemistry was controlled by kinetic and thermodynamic processes at lower and higher temperature, respectively. At 100 °C, the bis‐adducts were obtained in up to 99% yield and >99 : 1 d.r. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHOSPHINE oxides
STEREOCHEMISTRY
KINETIC control
ALKYNES
THERMODYNAMIC control
Subjects
Details
- Language :
- English
- ISSN :
- 21935807
- Volume :
- 9
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Asian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 142632869
- Full Text :
- https://doi.org/10.1002/ajoc.202000079