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Stereoselective Thermal Addition of RP and/or SP‐Menthyl‐Deriving Secondary Phosphine Oxides to Active Alkynes, the Mechanism, Stereochemistry and Generation of P,C‐Chirogenic Bis‐Phosphine Derivatives.

Stereoselective Thermal Addition of RP and/or SP‐Menthyl‐Deriving Secondary Phosphine Oxides to Active Alkynes, the Mechanism, Stereochemistry and Generation of P,C‐Chirogenic Bis‐Phosphine Derivatives.

Authors :
Yan, Bing‐Xia
Zheng, Hong‐Xing
Ye, Jing‐Jing
Qiu, Mao‐Ran
Zhang, Yu
Zhao, Chang‐Qiu
Li, Qiang
Source :
Asian Journal of Organic Chemistry; Apr2020, Vol. 9 Issue 4, p566-570, 5p
Publication Year :
2020

Abstract

The additions of RP‐1 or SP‐1 to alkynyl esters stereo selectively afforded bis‐phosphinylated derivatives having up to four C‐ and P‐chirogenic centers. The stereochemistry was controlled by kinetic and thermodynamic processes at lower and higher temperature, respectively. At 100 °C, the bis‐adducts were obtained in up to 99% yield and >99 : 1 d.r. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
21935807
Volume :
9
Issue :
4
Database :
Complementary Index
Journal :
Asian Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
142632869
Full Text :
https://doi.org/10.1002/ajoc.202000079