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Cross-linked small-molecule capsules with excitation wavelength-dependent photoluminescence and high loading capacity: design, synthesis and application in imaging-guided drug delivery.
- Source :
- Journal of Materials Chemistry B; 4/7/2020, Vol. 8 Issue 13, p2719-2725, 7p
- Publication Year :
- 2020
-
Abstract
- The cross-linked small-molecule micelles (cSMs) have found applications in many fields but their low loading capacity and non-fluorescence property hindered their further development. Herein, water-soluble organic nanoparticles were applied as templates to "stretch" the hydrophobic core of cSMs and photo-cross-linking was employed to supply photoluminescence. The resulting cross-linked small-molecule capsules (cSCs) not only reserve the superior properties of cSMs of accurate monomer, easy functionalization and robust stability, but also achieve high drug loading capacity and excitation wavelength-dependent fluorescence, where the drug loading contents (DLCs) for various hydrophobic drugs were more than 30-fold higher than that of cSMs, and the maximum quantum yield could be as high as 12.0%. Featuring these superiorities, the cSCs hold promising potential in many fields and an example of doxorubicin-loaded cSCs (DOX@cSCs) for multichannel imaging-guided drug delivery is shown in this work. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 8
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 142516243
- Full Text :
- https://doi.org/10.1039/c9tb02465d