Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies.

Authors :: Litvin, A. A.
Shevchenko, R. V.
Kolyvanov, G. B.
Bochkov, P. O.
Smirnov, V. V.
Raskin, S. Yu.
Gribakina, O. G.
Zherdev, V. P.
Kolik, L. G.
Gudasheva, T. A.
Ivashkina, N. Yu.
Source :: Pharmaceutical Chemistry Journal; Nov2019, Vol. 53 Issue 8, p685-688, 4p
Publication Year :: 2019
Abstract: Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and humans are presented. The elimination half-lives of the studied drugs are calculated in real (chronological) and corrected time (pharmacokinetic). Elimination half-lives in animals and volunteers are compared. Rabbits are found to be a better scaling model for GB-115 although a single preference for dilept was not found. [ABSTRACT FROM AUTHOR]

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