Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS2/SnO2.

Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS2@SnO2 nanocomposite as LMR supporting material and MoS2@SnO2 nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor’s performance has been studied for the CR concentration range from 0 to $2000~\mu \text{g}$ /mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/($\mu \text{g}$ /mL) and $1.86~\mu \text{g}$ /mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application. [ABSTRACT FROM AUTHOR]