Back to Search
Start Over
Bistachybotrysin K, one new phenylspirodrimane dimer from Stachybotrys chartarum with potent cytotoxic activity.
- Source :
- Journal of Asian Natural Products Research; May2020, Vol. 22 Issue 5, p496-502, 7p
- Publication Year :
- 2020
-
Abstract
- Bistachybotrysin K (1), one new phenylspirodrimane dimer with a central 6/7 oxygen heterocycle core, was isolated from the fungus Stachybotrys chartarum CGMCC 3.5365. Its structure was elucidated by extensive spectroscopic data and single-crystal X-ray diffraction. Compound 1 showed significant cytotoxicity against human tumor cell lines HCT116, NCI-H460, BGC823, Daoy, and HepG2 with IC<subscript>50</subscript> values in the range of 1.1–4.7 µM. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYDROCARBON analysis
ANTINEOPLASTIC agents
BIOLOGICAL assay
BIOLOGICAL products
CELL lines
CELL surface antigens
CRYSTALLOGRAPHY
FERMENTATION
FUNGI
HIGH performance liquid chromatography
HYDROCARBONS
IMMUNODIAGNOSIS
MASS spectrometry
MOLECULAR structure
RESEARCH funding
X-rays
DATA analysis software
CYTOTOXINS
DESCRIPTIVE statistics
IN vitro studies
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 22
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 142336484
- Full Text :
- https://doi.org/10.1080/10286020.2019.1680645