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HIV-infected children with moderate/severe immune-suppression: changes in the immune system after highly active antiretroviral therapy.
- Source :
- Clinical & Experimental Immunology; Sep2004, Vol. 137 Issue 3, p570-577, 8p
- Publication Year :
- 2004
-
Abstract
- The objective of this study was to monitor the changes in the immune system of HIV-infected children with moderate or severe immunodeficiency after highly active antiretroviral therapy (HAART), comprising a follow-up study in 14 HIV-infected children on HAART at two time points separated approximately by 11·8 ± 0·4 (9·9; 15·4) months. HIV-infected children had significantly lower TREC levels than the control group, but 1 year after HAART the levels increased significantly ( P < 0·05). In contrast, viral load (VL) did not change significantly. A positive correlation between T cell receptor excision circle (TREC) levels and both CD4<superscript>+</superscript> T cell absolute counts ( r = 0·558; P = 0·05) and percentages ( r = 0·625; P = 0·030) was found. During follow-up on HAART, the percentages and absolute counts of naive CD4<superscript>+</superscript> and CD8<superscript>+</superscript> T cell subsets were increased significantly ( P < 0·05). CD4<superscript>+</superscript> CD45RA<superscript>hi+</superscript> CD62L<superscript>+</superscript>, CD4<superscript>+</superscript> CD45RA<superscript>+</superscript> and CD4<superscript>+</superscript> CD38<superscript>+</superscript> percentages, and the CD8<superscript>+</superscript> CD45RA<superscript>hi+</superscript> CD62L<superscript>+</superscript> counts reached similar values to the control group. Also, CD8<superscript>+</superscript> CD45RO<superscript>+</superscript> CD38<superscript>+</superscript> and CD8<superscript>+</superscript> CD45RO<superscript>+</superscript> percentages, and CD8<superscript>+</superscript> CD45RO<superscript>+</superscript> CD38<superscript>+</superscript> absolute counts ( P < 0·05) decreased with respect to the baseline. Lymphoproliferative responses to pokeweed mitogen (PWM) before HAART were lower in HIV-infected children than the control group, but they recovered to normal levels after a year on HAART. Tumour necrosis factor (TNF)- α and interferon (IFN)- γ production by PHA-activated peripheral blood mononuclear cells (PBMC) was lower before HAART ( P < 0·001), but reached similar levels to the control group 1 year after HAART. In HIV-infected children IgG, IgG<subscript>1</subscript> and IgG<subscript>3</subscript> plasma levels decreased significantly after HAART. The immune system reconstitution induced by HAART in HIV-infected children seems to be the consequence of decreased immune system activation and naive T cell reconstitution, mainly of thymic origin. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYTOKINES
HIV
IMMUNE system
T cells
ANTIRETROVIRAL agents
JUVENILE diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 137
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14228213
- Full Text :
- https://doi.org/10.1111/j.1365-2249.2004.02583.x