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Effects of nedocromil sodium (TiladeĀ®) on the activation of human eosinophils and neutrophils and the release of histamine from mast cells.
- Source :
- Allergy; May88, Vol. 43 Issue 4, p268-276, 9p
- Publication Year :
- 1988
-
Abstract
- The ability of nedocromil sodium, a new anti-inflammatory agent for the treatment of asthma, to inhibit activation of human eosinophils and neutrophils <em>in vitro</em>, has been studied using an adherence reaction (the "rosette" technique) as well as a cytotoxicity assay. We have also investigated the capacity of nedocromil sodium to inhibit IgE-dependent histamine release from human lung mast cells. The drug was a potent inhibitor (IC<subscript>50</subscript> approx 5 × 10<superscript>-9</superscript>M) of fMLP-induced enhancement of eosinophil and neutrophil complement (C3b) and IgG (Fc) rosettes. There was also a comparable inhibition of enhancement, by fMLP, of eosinophil and neutrophil cytotoxicity (for complement-coated schistosomula of <em>Schistosoma mansoni</em>). Although nedocromil sodium also inhibited histamine release from human lung mast cells in a dose-dependent fashion its activity was relatively weak (IC<subscript>30</subscript> 5 × 10<superscript>-6</superscript>M) compared to its effect on granulocytes. These experiments support the view that the principal mode of action of nedocromil sodium is its capacity to inhibit the activation of inflammatory cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 43
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 14226957
- Full Text :
- https://doi.org/10.1111/j.1398-9995.1988.tb00899.x