Back to Search
Start Over
Active Ca Transport of Sarcoplasmic Reticulum during Experimental Uremia.
- Source :
- European Journal of Biochemistry; Jan76 Part 1, Vol. 61 Issue 1, p207-213, 7p
- Publication Year :
- 1976
-
Abstract
- The Ca-transport system of sarcoplasmic vesicles of rabbits is altered by experimental uremia. 1. The influx rate constant of the experimental membranes decrease with a resulting decrease of the calcium influx rate. 2. The experimental membranes transport a smaller amount of Ca<superscript>2+</superscript> per mol of ATP split than the controls, i.e. their transport ratio is decreased. 3. The calcium permeability of the experimental membranes increases with a resulting decreased concentrating ability. 4. The phosphatide content but not the cholesterol content of the experimental membranes de- creases with a consequent increase of the cholesterol/phosphatide ratio. 5. The fatty acid pattern of total phosphatides of the experimental membranes changes. A relative decrease of palmitic acid and oleic acid occurs and a relative increase of stearic, arachidonic and higher unsaturated fatty acids. 6. The altered lipid composition of the membranes does not change the temperature dependence of the kinetics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00142956
- Volume :
- 61
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 14223254
- Full Text :
- https://doi.org/10.1111/j.1432-1033.1976.tb10013.x