Formulation and Evaluation of Antioxidant Activity of Microspheres of Syzinium Cuminiextract.

Introduction: The main objective of the present investigation was to formulate micro particles of the Syzygiumcumini seeds extract and its evaluate its antioxidant activity. Material and methods: Extraction of crude drug was done using Solvent Extraction technique evaporation method.The extract-loaded microspheres using biological macromolecule ethyl cellulose (EC) was prepared by o/w emulsion solvent evaporation technique using polyvinyl alcohol (PVA) emulsifier. The formulated microspheres were evaluated for its entrapment efficiency, drug release, Chromatographic analysis, Total Phenolic and flavonoid content and Antioxidant activity by DPPH Model. Result and Discussion: Microparticles formulated showed good results of drug release and entrapment efficiency. Phenolics and flavonoid have been proved to be responsible for the antioxidant activity of various medicinal plants reported earlier. The result of DPPH model shows that microparticles have potent antioxidant activity. [ABSTRACT FROM AUTHOR]