Back to Search Start Over

Common and Disorder-Specific Neurofunctional Markers of Dysregulated Empathic Reactivity in Major Depression and Generalized Anxiety Disorder.

Authors :
Xu, Xiaolei
Dai, Jing
Liu, Congcong
Chen, Yuanshu
Xin, Fei
Zhou, Feng
Zhou, Xinqi
Huang, Yulan
Wang, Jinyu
Zou, Zhili
Li, Jialin
Ebstein, Richard P.
Kendrick, Keith M.
Zhou, Bo
Becker, Benjamin
Ebstein, Richard P
Kendrick, Keith M
Source :
Psychotherapy & Psychosomatics; 2020, Vol. 89 Issue 2, p114-116, 3p
Publication Year :
2020

Abstract

Post hoc analyses demonstrated that compared to HC, MDD patients exhibited exaggerated neural reactivity during affective pain yet attenuated reactivity during physical pain observation in this region, whereas GAD patients did not (Fig. 1. a Pain empathic neural reactivity was assessed using a validated pain empathy fMRI paradigm. b (i) Voxel-wise whole-brain ANOVA using cluster level FWE correction revealed a significant interaction effect in the right dorsal anterior insula (rdAI) spreading into the adjacent ventrolateral prefrontal cortex (vlPFC) (z = -1, y = 18, respectively). Attenuated rdAI reactivity during physical pain observation may in contrast reflect a decreased capacity for emotionally sharing other's physical pain, possibly associated to increased pain perception thresholds in MDD [[10]]. [Extracted from the article]

Details

Language :
English
ISSN :
00333190
Volume :
89
Issue :
2
Database :
Complementary Index
Journal :
Psychotherapy & Psychosomatics
Publication Type :
Academic Journal
Accession number :
142208762
Full Text :
https://doi.org/10.1159/000504180