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Common and Disorder-Specific Neurofunctional Markers of Dysregulated Empathic Reactivity in Major Depression and Generalized Anxiety Disorder.
- Source :
- Psychotherapy & Psychosomatics; 2020, Vol. 89 Issue 2, p114-116, 3p
- Publication Year :
- 2020
-
Abstract
- Post hoc analyses demonstrated that compared to HC, MDD patients exhibited exaggerated neural reactivity during affective pain yet attenuated reactivity during physical pain observation in this region, whereas GAD patients did not (Fig. 1. a Pain empathic neural reactivity was assessed using a validated pain empathy fMRI paradigm. b (i) Voxel-wise whole-brain ANOVA using cluster level FWE correction revealed a significant interaction effect in the right dorsal anterior insula (rdAI) spreading into the adjacent ventrolateral prefrontal cortex (vlPFC) (z = -1, y = 18, respectively). Attenuated rdAI reactivity during physical pain observation may in contrast reflect a decreased capacity for emotionally sharing other's physical pain, possibly associated to increased pain perception thresholds in MDD [[10]]. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00333190
- Volume :
- 89
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Psychotherapy & Psychosomatics
- Publication Type :
- Academic Journal
- Accession number :
- 142208762
- Full Text :
- https://doi.org/10.1159/000504180