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Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development.
- Source :
- Journal of Infectious Diseases; 2020 Supplement, Vol. 221, pS60-S73, 14p
- Publication Year :
- 2020
-
Abstract
- Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in "proof-of-concept" studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYTOMEGALOVIRUSES
HUMAN cytomegalovirus
ANIMAL models in research
VACCINES
RHESUS monkeys
CYTOMEGALOVIRUS disease prevention
PROTEIN metabolism
BIOLOGICAL models
VIRAL antigens
PROTEINS
VIRAL vaccines
IMMUNIZATION
CYTOMEGALOVIRUS diseases
PRIMATES
IMMUNITY
GENOMES
GENOMICS
RESEARCH funding
VERTICAL transmission (Communicable diseases)
MEDICAL research
ANIMALS
GUINEA pigs
INFECTIOUS disease transmission
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 221
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 142190196
- Full Text :
- https://doi.org/10.1093/infdis/jiz484