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Oxidation of an indole substrate by porphyrin iron(III) superoxide: relevance to indoleamine and tryptophan 2,3-dioxygenases.
- Source :
- Chemical Communications; 3/11/2020, Vol. 56 Issue 20, p3089-3092, 4p
- Publication Year :
- 2020
-
Abstract
- Reaction of Fe<superscript>III</superscript>(O<subscript>2</subscript>˙<superscript>−</superscript>)(TPP) with 2,3-dimethylindole at −40 °C gives the ring-opened, dioxygenated N-(2-acetyl-phenyl)-acetamide product. The reaction was monitored in situ by low-temperature UV-vis and <superscript>1</superscript>H NMR spectroscopies. This work demonstrates that a discrete iron(III)(superoxo) porphyrin is competent to carry out indole oxidation, as proposed for the tryptophan and indoleamine 2,3-dioxygenases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 20
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 142160889
- Full Text :
- https://doi.org/10.1039/c9cc10019a