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Lifetime Risk Factors for Pre- and Post-Bronchodilator Lung Function Decline. A Population-based Study.
- Source :
- Annals of the American Thoracic Society; Mar2020, Vol. 17 Issue 3, p302-E12, 23p
- Publication Year :
- 2020
-
Abstract
- Rationale: Interactions between early life and adult insults on lung function decline are not well understood, with most studies investigating prebronchodilator (pre-BD) FEV1 decline.Objectives: To investigate relationships between adult risk factors and pre- and post-BD lung function decline and their potential effect modification by early life and genetic factors.Methods: Multiple regression was used to examine associations between adult exposures (asthma, smoking, occupational exposures, traffic pollution, and obesity) and decline in both pre- and post-BD spirometry (forced expiratory volume in 1 s [FEV1], forced vital capacity [FVC], and FEV1/FVC) between ages 45 and 53 years in the Tasmanian Longitudinal Health Study (nā=ā857). Effect modification of these relationships by childhood respiratory risk factors, including low childhood lung function and GST (glutathione S-transferase) gene polymorphisms, was investigated.Results: Baseline asthma, smoking, occupational exposure to vapors/gases/dusts/fumes, and living close to traffic were associated with accelerated decline in both pre- and post-BD FEV1. These factors were also associated with FEV1/FVC decline. Occupational exposure to aromatic solvents was associated with pre-BD but not post-BD FEV1 decline. Maternal smoking accentuated the effect of personal smoking on pre- and post-BD FEV1 decline. Lower childhood lung function and having the GSTM1 null allele accentuated the effect of occupational exposure to vapors/gases/dusts/fumes and personal smoking on post-BD FEV1 decline. Incident obesity was associated with accelerated decline in FEV1 and more pronounced in FVC.Conclusions: This study provides new evidence for accentuation of individual susceptibility to adult risk factors by low childhood lung function, GSTM1 genotype, and maternal smoking. [ABSTRACT FROM AUTHOR]
- Subjects :
- PULMONARY function tests
DISEASE risk factors
BRONCHODILATOR agents
GENETIC polymorphisms
ASTHMA
OBESITY
RESEARCH
DUST
GASES
LUNGS
LUNG diseases
RESEARCH methodology
SOCIAL networks
RESPIRATORY measurements
OCCUPATIONAL exposure
REGRESSION analysis
MEDICAL cooperation
EVALUATION research
COMPARATIVE studies
PSYCHOLOGICAL tests
FORCED expiratory volume
TRANSFERASES
DISEASE susceptibility
QUESTIONNAIRES
RESEARCH funding
SMOKING
SPIROMETRY
LONGITUDINAL method
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 23296933
- Volume :
- 17
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Annals of the American Thoracic Society
- Publication Type :
- Academic Journal
- Accession number :
- 142017727
- Full Text :
- https://doi.org/10.1513/AnnalsATS.201904-329OC