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IgG subclass antibodies against <em>Parietaria Judaica</em> in normal and allergic subjects.
- Source :
- Allergy; Apr94, Vol. 49 Issue 4, p222-229, 8p
- Publication Year :
- 1994
-
Abstract
- IgG antibody response to the inhalant allergen <em>Parietaria judaica</em> (Pj) and IgG subclass distribution were studied in 82 normal subjects, divided into three groups according to age (0-1, 1-20, and 20-60 years) and in 32 allergic subjects aged 20-60 years. Both normal and allergic subjects showed an IgG response, and all had IgG 1 antibodies specific for PjE. Serum IgG2, IgG3, and IgG4 against PjE were detectable in 36%, 46%, and 22% of normal subjects, and in 58%, 31%, and 65% of allergic subjects, respectively. A significant difference in class distribution between allergic and age-matched normal subjects was found only for IgG4 antibodies against PjE (65% and 17%; <em>P</em> < 0.01). The ELISA results were also analyzed quantitatively, taking into account the relative proportion of specific antibodies. Thus, in normal subjects IgG 1 antibodies showed a decreasing trend as the age rose, while no differences according to the age of the subject were found for IgG2 and IgG4. When data from allergic subjects (20-60 years) and the age-matched normal group were compared, they were different for the relative percentage of IgG2 only, showing for this a significantly lower value (<em>P</em> < 0.001). The present data indicate that normal and allergic subjects show differences in the IgG iso type distribution depending on their sensitivity and duration of allergen exposure. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOGLOBULINS
ALLERGENS
GLOBULINS
PLASMA cells
BLOOD proteins
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 49
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 14197133
- Full Text :
- https://doi.org/10.1111/j.1398-9995.1994.tb02653.x