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Neuron-specific enolase is correlated with lesion topology, relative infarct volume and outcome of symptomatic NAIS.
- Source :
- Archives of Disease in Childhood -- Fetal & Neonatal Edition; Mar2020, Vol. 105 Issue 2, pF132-F137, 6p
- Publication Year :
- 2020
-
Abstract
- <bold>Objective: </bold>To correlate neuron-specific enolase (NSE) levels in cerebrospinal fluid (CSF) in neonate infants with symptomatic neonatal arterial ischaemic stroke (NAIS) with the arterial distribution of infarct, infarct volume and outcome.<bold>Design: </bold>Prospective observational multicentre cohort.<bold>Setting: </bold>Three paediatric university hospitals in Spain.<bold>Subjects: </bold>Thirty-eight neonates with more than 35 weeks' gestational age between 2006 and 2016 were studied. They were diagnosed with NAIS by MRI. They underwent a lumbar puncture to measure CSF-NSE concentrations within 96 hours after the onset of symptoms. Sixty-seven neonates admitted with suspected infections served as controls. We used a classification based on the arterial distribution, and the lesions were segmented with ITK-Snap software to determine their volume. Neurodevelopment was assessed at 24 months using the Bayley-III, Gross Motor Function Classification System and Bimanual Fine Motor Function.<bold>Results: </bold>CSF-NSE levels were higher in patients with symptomatic NAIS when compared with controls. Neonates with multifocal NAIS and with NAIS located in middle cerebral artery (MCA)-M1 arterial territory showed higher CSF-NSE levels when compared with cases with MCA-M2-M3-M4 territories (p<0.001). A significant correlation was found between CSF-NSE and relative infarction volume (rs=0.597; p<0.001). CSF-NSE values were higher in those infants with symptomatic NAIS with adverse outcome compared with infants with good development (p=0.020). Infants with CSF-NSE values above 55 ng/mL had an OR of adverse outcome of 6.48 (95% CI 1.48 to 28.33).<bold>Conclusions: </bold>CSF-NSE is a potential early prognostic biomarker after an NAIS due to the relation between volume, topology and neurodevelopment at 2 years of age. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENOLASE
INFANT development
NEWBORN infants
CEREBROSPINAL fluid
GESTATIONAL age
RESEARCH
STROKE
ACADEMIC medical centers
INFARCTION
CHILD development
RESEARCH methodology
MAGNETIC resonance imaging
EVALUATION research
MEDICAL cooperation
COMPARATIVE studies
ENZYMES
CEREBRAL ischemia
LONGITUDINAL method
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 13592998
- Volume :
- 105
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Archives of Disease in Childhood -- Fetal & Neonatal Edition
- Publication Type :
- Academic Journal
- Accession number :
- 141923970
- Full Text :
- https://doi.org/10.1136/archdischild-2018-316680