Depression increases in women during early to late menopause but decreases after menopause.

The article discusses finding of a research which suggests that depression increases in women during early to late menopause but decreases after menopause. Although there is suggestive evidence from observational studies that oestrogen therapy improves mood and cognition, the clinical relevance of oestrogens is unproved. There are weak data that oestrogens might be considered for mild depressive symptoms attributed to hot flushes, sleep disorder or climacteric symptoms. No hard data exist to indicate whether oestrogens could be used as adjunctive therapy for other depressive disorders during the menopausal transition.