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Bone and skeletal muscle changes in oldest-old women: the role of physical inactivity.
- Source :
- Aging Clinical & Experimental Research; Feb2020, Vol. 32 Issue 2, p207-214, 8p
- Publication Year :
- 2020
-
Abstract
- Background: Alterations in bone and muscle parameters related to advanced aging and physical inactivity have never been investigated in oldest-old women. Aims: To investigate the impact of physical inactivity on bone mineral density (BMD) and body composition at the systemic and regional levels in oldest-old (> 75 years old) women. We hypothesized that, further to aging, alterations in bone and body composition parameters are exacerbated in the locomotor limbs that have experienced physical inactivity. Methods: Whole-body and regional (lower limbs and trunk) BMD and fat-free soft tissue mass (FFSTM) were measured by means of dual-energy X-ray absorptiometry in 11 oldest-old wheelchair-bound women (OIW), 11 oldest-old mobile women (OMW), and 11 young healthy women (YW), all matched for weight (± 10 kg), height (± 10 cm). Results: Whole-body BMD was reduced by 15% from YW to OMW and 10% from OMW to OIW. Whole-body FFSTM was also reduced from YW to OIW (− 13%). Lower limb BMD was progressively reduced among YW, OMW and OIW (− 23%). Similarly, lower limb FFSTM was reduced among YW (12,816 ± 1797 g), OMW (11,999 ± 1512 g) and OIW (10,037 ± 1489 g). Trunk BMD was progressively reduced among YW, OMW and OIW (− 19%), while FFSTM was similar among the three groups ~ 19801 g. Conclusions: The results of the present study suggest that the alterations in bone and body composition parameters are exacerbated in the physical inactive oldest-old. These negative effects of physical inactivity are not confined to the locomotor limbs, and a systemic decline of bone and muscle parameters are likely associated with the physical inactivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15940667
- Volume :
- 32
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Aging Clinical & Experimental Research
- Publication Type :
- Academic Journal
- Accession number :
- 141859579
- Full Text :
- https://doi.org/10.1007/s40520-019-01352-x