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Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways.
- Source :
- Journal of Asian Natural Products Research; Apr2020, Vol. 22 Issue 4, p386-396, 11p
- Publication Year :
- 2020
-
Abstract
- The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANIMAL experimentation
ANTINEOPLASTIC agents
ASPARTATE aminotransferase
BROCCOLI
CABBAGE
CYTOKINES
DIABETES
INFLAMMATION
INTERLEUKINS
INTRAVENOUS therapy
LIVER failure
MICE
TRANSFERASES
DNA-binding proteins
PHYTOCHEMICALS
ALANINE aminotransferase
TREATMENT effectiveness
LIPOPOLYSACCHARIDES
TOLL-like receptors
DESCRIPTIVE statistics
BLOOD
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 22
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 141801764
- Full Text :
- https://doi.org/10.1080/10286020.2019.1581174