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Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer.

Authors :
Mao, Yun
Peng, Xi
Xue, Peng
Lu, Dianrong
Li, Linlu
Zhu, Shijie
Source :
Evidence-based Complementary & Alternative Medicine (eCAM); 2/17/2020, p1-13, 13p, 4 Diagrams, 2 Charts, 4 Graphs
Publication Year :
2020

Abstract

Cinobufotalin injection, extracted from the skin of Chinese giant salamander or black sable, has good clinical effect against lung cancer. However, owing to its complex composition, the pharmacological mechanism of cinobufotalin injection has not been fully clarified. This study aimed to explore the mechanism of action of cinobufotalin injection against lung cancer using network pharmacology and bioinformatics. Compounds of cinobufotalin injection were determined by literature retrieval, and potential therapeutic targets of cinobufotalin injection were screened from Swiss Target Prediction and STITCH databases. Lung-cancer-related genes were summarized from GeneCards, OMIM, and DrugBank databases. The pharmacological mechanism of cinobufotalin injection against lung cancer was determined by enrichment analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes, and protein-protein interaction network was constructed. We identified 23 compounds and 506 potential therapeutic targets of cinobufotalin injection, as well as 70 genes as potential therapeutic targets of cinobufotalin injection in lung cancer by molecular docking. The antilung cancer effect of cinobufotalin injection was shown to involve cell cycle, cell proliferation, antiangiogenesis effect, and immune inflammation pathways, such as PI3K-Akt, VEGF, and the Toll-like receptor signaling pathway. In network analysis, the hub targets of cinobufotalin injection against lung cancer were identified as VEGFA, EGFR, CCND1, CASP3, and AKT1. A network diagram of "drug-compounds-target-pathway" was constructed through network pharmacology to elucidate the pharmacological mechanism of the antilung cancer effect of cinobufotalin injection, which is conducive to guiding clinical medication. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1741427X
Database :
Complementary Index
Journal :
Evidence-based Complementary & Alternative Medicine (eCAM)
Publication Type :
Academic Journal
Accession number :
141768370
Full Text :
https://doi.org/10.1155/2020/1246742