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Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 2/17/2020, p1-13, 13p, 4 Diagrams, 2 Charts, 4 Graphs
- Publication Year :
- 2020
-
Abstract
- Cinobufotalin injection, extracted from the skin of Chinese giant salamander or black sable, has good clinical effect against lung cancer. However, owing to its complex composition, the pharmacological mechanism of cinobufotalin injection has not been fully clarified. This study aimed to explore the mechanism of action of cinobufotalin injection against lung cancer using network pharmacology and bioinformatics. Compounds of cinobufotalin injection were determined by literature retrieval, and potential therapeutic targets of cinobufotalin injection were screened from Swiss Target Prediction and STITCH databases. Lung-cancer-related genes were summarized from GeneCards, OMIM, and DrugBank databases. The pharmacological mechanism of cinobufotalin injection against lung cancer was determined by enrichment analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes, and protein-protein interaction network was constructed. We identified 23 compounds and 506 potential therapeutic targets of cinobufotalin injection, as well as 70 genes as potential therapeutic targets of cinobufotalin injection in lung cancer by molecular docking. The antilung cancer effect of cinobufotalin injection was shown to involve cell cycle, cell proliferation, antiangiogenesis effect, and immune inflammation pathways, such as PI3K-Akt, VEGF, and the Toll-like receptor signaling pathway. In network analysis, the hub targets of cinobufotalin injection against lung cancer were identified as VEGFA, EGFR, CCND1, CASP3, and AKT1. A network diagram of "drug-compounds-target-pathway" was constructed through network pharmacology to elucidate the pharmacological mechanism of the antilung cancer effect of cinobufotalin injection, which is conducive to guiding clinical medication. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELL proliferation
CELL cycle
CELL lines
CELLULAR signal transduction
COMPUTER simulation
DATABASES
EPIDERMAL growth factor
GENETIC research
GENOMES
INFLAMMATORY mediators
INJECTIONS
LUNG tumors
METABOLISM
PROTEIN kinases
TISSUE extracts
BIOINFORMATICS
VASCULAR endothelial growth factors
CASPASES
TOLL-like receptors
PATHOLOGIC neovascularization
CELL cycle proteins
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 141768370
- Full Text :
- https://doi.org/10.1155/2020/1246742