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A procalcitonin photoelectrochemical immunosensor: NCQDs and Sb2S3 co-sensitized hydrangea-shaped WO3 as a matrix through a layer-by-layer assembly.
- Source :
- New Journal of Chemistry; 2/14/2020, Vol. 44 Issue 6, p2452-2458, 7p
- Publication Year :
- 2020
-
Abstract
- Using nitrogen-doped carbon quantum dots (NCQDs) and antimony trisulfide (Sb<subscript>2</subscript>S<subscript>3</subscript>) to co-sensitize hydrangea-shaped tungsten trioxide (WO<subscript>3</subscript>), a novel photoelectrochemical (PEC) immunosensor was constructed to sensitively detect procalcitonin (PCT). WO<subscript>3</subscript> possessed a three-dimensional structure with uniform size and large surface area on the indium tin oxide (ITO) electrode. NCQDs with abundant carboxy groups and excitation-independent PEC behavior were modified on the surface of the WO<subscript>3</subscript> coating to enhance photochemical activity. Hence, the hydrangea-shaped WO<subscript>3</subscript>/NCQDs/Sb<subscript>2</subscript>S<subscript>3</subscript> composite was obtained by modifying NCQDs and well-crystallized Sb<subscript>2</subscript>S<subscript>3</subscript> nanoparticles on WO<subscript>3</subscript> through a layer-by-layer assembly. It is worth noting that the photoelectric signal of WO<subscript>3</subscript>/NCQDs/Sb<subscript>2</subscript>S<subscript>3</subscript> was about 8 times that of pure WO<subscript>3</subscript> under visible light excitation. Moreover, the PEC immunosensor showed a large-scale response (0.001–100 ng mL<superscript>−1</superscript>) and a low detection limit (0.42 pg mL<superscript>−1</superscript>) under the best experimental conditions. This PEC immunosensor has advantages such as simplicity, facile fabrication, high sensitivity and strong stability, which have good research value in the analysis and detection of disease biomarkers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 44
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 141667608
- Full Text :
- https://doi.org/10.1039/c9nj06118e