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ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells.
- Source :
- Molecular & Cellular Oncology; 2020, Vol. 7 Issue 1, p1-3, 3p
- Publication Year :
- 2020
-
Abstract
- Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through the activation of a fibroblast growth factor autocrine signaling loop, which can be blocked pharmacologically. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 7
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 141655570
- Full Text :
- https://doi.org/10.1080/23723556.2019.1684787