Eradication of Helicobacter pylori Infection Decreases Risk for Dyslipidemia: A Cohort Study.

Background/Aims Previous studies have suggested a link between Helicobacter pylori infection and dyslipidemia, yet large-scale longitudinal studies have not elucidated this association. Therefore, we assessed the longitudinal effects of both H. pylori infection and eradication on lipid profiles in a large cohort of asymptomatic men and women. Methods This cohort study included 18,621 adults without dyslipidemia at baseline, who participated in a repeated, regular health screening examination, which included upper gastrointestinal endoscopy, between January 2009 and December 2018. The primary outcome was incident dyslipidemia at follow-up. Results During the 52,992 person-years follow-up, participants with persistent H. pylori infection had a higher incidence rate (177 per 1,000 person-years) of dyslipidemia than those whose infections had been successfully eradicated (158.2 per 1,000 person-years) and those who were uninfected (157.6 per 1,000 person-years). In a multivariable model adjusted for age, sex, body mass index, smoking status, alcohol intake, and baseline levels of low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and triglyceride, the H. pylori eradication group was associated with a lower risk of dyslipidemia than the persistent group (hazard ratio, 0.89; 95% confidence interval, 0.82 to 0.96; p=0.005). The risk of dyslipidemia in the eradication group was similar to that of participants uninfected with H. pylori (p=0.245). Conclusions Persistent H. pylori infection was significantly associated with the risk of dyslipidemia. H. pylori infection may play a pathophysiologic role in the development of dyslipidemia and H. pylori eradication might decrease the risk of dyslipidemia. [ABSTRACT FROM AUTHOR]