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Indium controlled regioselective 1,4-alkylarylation of 1,3-dienes with α-carbonyl alkyl bromides and N-heterocycles.
- Source :
- Chemical Communications; 1/25/2020, Vol. 56 Issue 8, p1279-1282, 4p
- Publication Year :
- 2020
-
Abstract
- We here describe a new, selective indium-promoted silver-mediated intermolecular oxidative 1,4-alkylarylation of 1,3-dienes with α-carbonyl alkyl bromides and N-heterocycles for producing functionalized N-heterocycles, which is characterized by its exquisitely controllable regio-/stereo-selectivity and excellent tolerance of functional groups. Mechanistically, the formation of the carbonyl-coordinated η<superscript>3</superscript>-allyl-In complex radical intermediate is the key factor for successfully achieving regio- and stereo-selectivity toward 1,4-difunctionalization and (E)-isomers. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALKYL bromides
INDIUM
FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 141430458
- Full Text :
- https://doi.org/10.1039/c9cc08903a