Back to Search
Start Over
Influenza Vaccine Efficacy and Effectiveness in Pregnant Women: Systematic Review and Meta-analysis.
- Source :
- Maternal & Child Health Journal; Feb2020, Vol. 24 Issue 2, p229-240, 12p, 1 Diagram, 5 Charts
- Publication Year :
- 2020
-
Abstract
- Objective: Pregnant women have a high risk for complications from influenza infection, but vaccination rates within this group remain low in the US and other countries. The efficacy and effectiveness of the influenza vaccine are a key determinant of vaccine uptake. This review aimed to synthesize the available evidence on the protection of both seasonal and monovalent pandemic H1N1 (pdmH1N1) vaccine against laboratory-confirmed influenza (LCI), influenza-like illness (ILI), and respiratory illness (RI). Methods: A search of the literature was undertaken from Pubmed, Embase, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials up to Aug 1, 2018. Both observational studies and clinical trials were considered. Results: Nineteen studies were identified from 11 countries. Women with pdmH1N1 vaccination had a lower risk of getting LCI (Relative risk [RR] 0.3, 95% confidence interval [CI] 0.26–0.35) and ILI (RR 0.15, 95% CI 0.06–0.36)). The pooled estimate from three randomized clinical trials (RR 0.47, 95% CI 0.31–0.71) and two case control studies (OR 0.37, 95% CI 0.23–0.61) showed that the seasonal vaccine was protective against LCI. The seasonal vaccine was not protective against ILI (RR 0.95, 95% CI 0.88–1.03). This association was similar for the outcome of RI (RR 0.81, 95% CI 0.55–1.20). Conclusion: This analysis bolsters existing evidence that influenza vaccines are effective among pregnant women. Additional public health efforts are needed to promote physician recommendations of influenza vaccination in pregnancy. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLUENZA prevention
CONFIDENCE intervals
IMMUNIZATION
INFLUENZA vaccines
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL information storage & retrieval systems
MEDLINE
META-analysis
ONLINE information services
PREGNANT women
RESPIRATORY infections
SYSTEMATIC reviews
RELATIVE medical risk
TREATMENT effectiveness
DATA analysis software
DESCRIPTIVE statistics
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 10927875
- Volume :
- 24
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Maternal & Child Health Journal
- Publication Type :
- Academic Journal
- Accession number :
- 141385679
- Full Text :
- https://doi.org/10.1007/s10995-019-02844-y