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Periodontal pathogens and their role in cardiovascular outcome.
- Source :
- Journal of Clinical Periodontology; Feb2020, Vol. 47 Issue 2, p173-181, 9p, 3 Charts, 1 Graph
- Publication Year :
- 2020
-
Abstract
- Aim: Periodontitis has been identified as a moderate but independent risk factor for cardiovascular (CV) disease and progression. The objective of this study (ClinicalTrials.gov Identifier: NCT01045070) was to assess subgingival colonization with selected periodontal pathogens on the occurrence of further adverse CV events in a cohort of CV patients. Methods: The prevalence of severe periodontitis including the detection of 11 periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Treponema denticola, P. intermdia, Peptostreptococcus micros, Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, Capnocytophaga sputigena, Capnocytophaga gingivalis, Capnocytophaga ochracea; HAIN‐Diagnostica®) was analysed in 1,002 CV patients The prognostic impact of periodontal pathogens for combined CV endpoint (stroke/TIA, myocardial infarction, CV death, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios (HRs) were adjusted for established CV risk factors applying Cox regression. Results: In the Kaplan–Meier analysis (log‐rank test: p <.001) and Cox regression (HR: 0.545, 95%‐CI: 0.387–0.773; p =.001), the decreased occurrence of E. corrodens was shown to be an independent predictor for adverse CV events after 3 years of follow‐up. Conclusions: The detection of E. corrodens was associated with a reduced risk of adverse CV events in patients with CV disease. The pathophysiological background underlying this association should be investigated in further studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- MYOCARDIAL infarction risk factors
STROKE-related mortality
CAMPYLOBACTER
CARDIOVASCULAR diseases
CARDIOVASCULAR diseases risk factors
CONFIDENCE intervals
GRAM-negative bacteria
GRAM-positive bacteria
GINGIVA
HOST-bacteria relationships
LONGITUDINAL method
PERIODONTITIS
REGRESSION analysis
RISK assessment
TRANSIENT ischemic attack
DISEASE prevalence
PROPORTIONAL hazards models
SEVERITY of illness index
KAPLAN-Meier estimator
GRAM-negative anaerobic bacteria
LOG-rank test
ODDS ratio
DISEASE complications
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 47
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 141275278
- Full Text :
- https://doi.org/10.1111/jcpe.13224