Reply to "Pregnancy, N-Methyl-D-Aspartate Receptor Antibodies, and Neuropsychiatric Diseases".

For this, our murine model demonstrates that low-level maternal NMDAR autoantibodies (at serum titers similar to those of antibody-positive mothers) can lead to persisting neurodevelopmental changes and behavioral abnormalities in the offspring, resembling several features of psychiatric disease models.[1] Additionally, to further refine our animal models, we suggest using a variety of NMDAR antibodies derived from different mothers, as well as autoantibodies targeting other receptors besides the NMDAR.[2] In any case, we feel that the best example of our maternofetal transfer model is not NMDAR encephalitis, but the clinically and experimentally much better understood myasthenia gravis with low-level autoantibodies against the fetal acetylcholine receptor (AChR). [Extracted from the article]