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Terpenes and lignans from the roots of Solanum melongena L.
- Source :
- Natural Product Research; Feb2020, Vol. 34 Issue 3, p359-368, 10p
- Publication Year :
- 2020
-
Abstract
- Phytochemical investigation of the roots of Solanum melongena L. resulted in the isolation of ten terpenes and sixteen lignans, including a new triterpene saponin, officinoterpenoside E (1) and twenty-five known compounds (2-26). All compounds were firstly isolated from S. melongena except 2, 13, 21, 22. The structures of these compounds were determined by 1 D and 2 D NMR spectra referring to the literatures, together with high-resolution mass spectrometric analysis. All compounds were evaluated for the cytotoxicity against three cancer cell lines (HepG2, Hela, and MCF-7) in vitro. The results showed that compounds 1, 6, 20, 25 and 26 exhibited moderate cytotoxicity against HepG2, Hela and MCF-7 cells with IC<subscript>50</subscript> values in the range of 16.8 ± 1.7 to 29.1 ± 1.9 μM. Therefore, these terpenoids and lignans may have potential biological activity, and also seemed to be of great chemotaxonomic value for S. melongena. [ABSTRACT FROM AUTHOR]
- Subjects :
- EGGPLANT
LIGNANS
TERPENES
HELA cells
CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 34
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 141207667
- Full Text :
- https://doi.org/10.1080/14786419.2018.1533828