Back to Search Start Over

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis.

Authors :
Bélanger, Audrey
Grenier, Alexe
Simard, François
Gendreau, Isabelle
Pichette, André
Legault, Jean
Pouliot, Roxane
Source :
International Journal of Molecular Sciences; Jan2020, Vol. 21 Issue 1, p256, 1p, 3 Diagrams, 3 Charts, 1 Graph
Publication Year :
2020

Abstract

Psoriasis is a skin disorder characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. The treatments currently available on the market only improve patients' quality of life and are associated with undesirable side effects. Thus, research leading to the development of new, effective, and safer therapeutic agents is still relevant. Populus balsamifera L. buds were used traditionally by Native Americans to treat various skin pathologies such as eczema and psoriasis. In this study, the antipsoriatic activities of dihydrochalcone derivatives from Populus balsamifera L. buds, known as balsacones, were investigated. The experiments were performed in vitro using a psoriatic skin substitute model. Also, anti-inflammatory and antioxidant activities were investigated. The tested balsacones showed promising antipsoriatic properties by slowing down cell growth and by regulating the expression of involucrin, loricrin, and Ki67 better than methotrexate in psoriatic substitutes. All five tested compounds could be an effective topical treatment for psoriasis, with promising anti-inflammatory and antioxidant actions that may contribute to clinical improvement in patients with psoriasis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
21
Issue :
1
Database :
Complementary Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
141128186
Full Text :
https://doi.org/10.3390/ijms21010256