Back to Search
Start Over
Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep.
- Source :
- American Journal of Physiology: Lung Cellular & Molecular Physiology; Jan2020, Vol. 318 Issue 1, pL41-L48, 8p
- Publication Year :
- 2020
-
Abstract
- Mechanical ventilation from birth with normal tidal volumes (V<subscript>T</subscript>) causes lung injury and systemic responses in preterm sheep. The addition of budesonide to surfactant therapy decreases these injury markers. Budesonide and surfactant will decrease the injury from injurious V<subscript>T</subscript> ventilation in preterm sheep. Lambs at 126 ± 1 day gestational age were ventilated from birth with either: 1) Normal V<subscript>T</subscript> [surfactant 200 mg/kg before ventilation, positive end expiratory pressure (PEEP) 5 cmH<subscript>2</subscript>O, V<subscript>T</subscript> 8 mL/kg] or 2) Injury V<subscript>T</subscript> (high pressure, 100% oxygen, no PEEP) for 15 min, then further randomized to surfactant + saline or surfactant + 0.25 mg/kg budesonide with Normal V<subscript>T</subscript> for 6 h. Lung function and lung, liver, and brain tissues were evaluated for indicators of injury. Injury V<subscript>T</subscript> + saline caused significant injury and systemic responses, and Injury V<subscript>T</subscript> + budesonide improved lung physiology. Budesonide decreased lung inflammation and decreased pro-inflammatory cytokine mRNA in the lung, liver, and brain to levels similar to Normal V<subscript>T</subscript> + saline. Budesonide was present in plasma within 15 min of treatment in both ventilation groups, and less than 5% of the budesonide remained in the lung at 6 h. mRNA sequencing of liver and periventricular white matter demonstrated multiple pathways altered by both Injury V<subscript>T</subscript> and budesonide and the combination exposure. In lambs receiving Injury V<subscript>T</subscript>, the addition of budesonide to surfactant improved lung physiology and decreased pro-inflammatory cytokine responses in the lung, liver, and brain to levels similar to lambs receiving Normal V<subscript>T</subscript>. [ABSTRACT FROM AUTHOR]
- Subjects :
- SURFACE active agents
SHEEP
LUNGS
LUNG injuries
PNEUMONIA
HYDROXYPROGESTERONE
Subjects
Details
- Language :
- English
- ISSN :
- 10400605
- Volume :
- 318
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- American Journal of Physiology: Lung Cellular & Molecular Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 141038424
- Full Text :
- https://doi.org/10.1152/ajplung.00203.2019