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Laboratory Approach to Hemolytic Anemia.
- Source :
- Indian Journal of Pediatrics; Jan2020, Vol. 87 Issue 1, p66-74, 9p
- Publication Year :
- 2020
-
Abstract
- Hemolytic anemias are a group of disorders with varied clinical and molecular heterogeneity. They are characterized by decreased levels of circulating erythrocytes in blood. The pathognomic finding is a reduced red cell life span with severe anemia or, compensated hemolysis accompanied by reticulocytosis. The diagnostic workup or laboratory approach for hemolytic anemias is based on methodical step-wise testing which includes red blood cell morphology, hematological indices with increased reticulocyte count along with clinical features of hemolytic anemias. If conventional laboratory tests are unable to detect the underlying cause of hemolysis, genetic testing is recommended. Sanger sequencing along with conventional testing is the most efficient way to diagnose the underlying genetic causes, especially in thalassemias/hemoglobinopathies, if required. However, hemolytic anemias being highly heterogeneous disorders, next-generation sequencing-based screening is rapidly becoming an efficient way to decipher the etiologies where common causes have been excluded. [ABSTRACT FROM AUTHOR]
- Subjects :
- THALASSEMIA diagnosis
HEMOLYTIC anemia diagnosis
HEMOGLOBINOPATHY diagnosis
HEMOLYTIC anemia
CLINICAL pathology
SEQUENCE analysis
RETICULOCYTES
HEMOLYSIS & hemolysins
GENETIC testing
TRANSFERASES
BLOOD diseases
INBORN errors of metabolism
BLOOD testing
ERYTHROCYTES
BLOOD cell count
CONGENITAL hemolytic anemia
Subjects
Details
- Language :
- English
- ISSN :
- 00195456
- Volume :
- 87
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Indian Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 141002895
- Full Text :
- https://doi.org/10.1007/s12098-019-03119-8