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Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark.
- Source :
- Acta Dermato-Venereologica; Dec2019, Vol. 99 Issue 13, p1231-1236, 6p
- Publication Year :
- 2019
-
Abstract
- Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathological data for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients' mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01). All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8-) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort. [ABSTRACT FROM AUTHOR]
- Subjects :
- SEZARY syndrome
SKIN disease diagnosis
CUTANEOUS T-cell lymphoma
MYCOSIS fungoides
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 99
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 140344451
- Full Text :
- https://doi.org/10.2340/00015555-3351