Effect of lansoprazole on acute and sub-acute models of inflammation in male Wistar rats: an experimental study.

Aims & Objective: To evaluate effect of lansoprazole on acute and sub-acute models of inflammation in rats. Materials and Methods: The study was carried out in two models of inflammation viz; carrageenan induced rat paw edema and foreign body induced granuloma. Animals were divided into three groups. Control group received 0.5ml of 1% gum acacia suspension while test groups received lansoprazole and aspirin. The rat paw volume was measured with the help of a mercury plethysmograph at regular intervals and percentage inhibition of edema was calculated. In sub-acute model of inflammation, two sterile cotton pellets and two sterile grass piths were implanted subcutaneously in the axilla and groin. The treatment was started on the day of implantation and was repeated every twenty-four hours, regularly, for ten days. On eleventh day, rats were sacrificed and mean granuloma dry weight of cotton pellets for various groups was calculated. The sections of grass piths were sent for histopathological studies. Results: In the present study, lansoprazole showed significant anti-inflammatory effect in acute as well as sub-acute models of inflammation when compared to control. Conclusion: Lansoprazole showed anti-inflammatory effect in the current study. [ABSTRACT FROM AUTHOR]