It is time to reconsider the risks of transfusing RhD negative females of childbearing potential with RhD positive red blood cells in bleeding emergencies.

This figure is factually accurate, however it is derived from studies of I healthy i D- volunteers who received D+ RBCs 40-50 years ago.[[21]] In today's era of patient blood management and evidence-based transfusion decisions, healthy people are rarely transfused with RBCs. However, if faced with the prospect of death from massive bleeding or the manageable risks of alloimmunization in the future, it is time to reconsider the risk of transfusing D- FCPs with D+ RBCs in the trauma and massive transfusion settings. Give the trauma patient what they bleed, when and where they need it: establishing a comprehensive regional system of resuscitation based on patient need utilizing cold-stored, low-titer O+ whole blood. [Extracted from the article]