Investigating modifications to participant information materials to improve recruitment into a large randomized trial.

The article examines potential reasons behind a decline in the response of potential participants to mailed invitations to participate in large randomized trials to test treatment efficacy and safety. It states focus groups were used to examine reasons for the failure of potential participants to take part in the studies. It mentions a lack of transportation and mobility issues were the most common reason given in declining invitations along with concerns about treatment side-effects.