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Risk of Dementia in Gastric Cancer Survivors Who Underwent Gastrectomy: A Nationwide Study in Korea.
- Source :
- Annals of Surgical Oncology: An Oncology Journal for Surgeons; Dec2019, Vol. 26 Issue 13, p4229-4237, 9p
- Publication Year :
- 2019
-
Abstract
- Purpose: This study was designed to compare the risk of dementia, including Alzheimer's disease (AD) and vascular dementia (VaD), between gastric cancer patients who underwent gastrectomy and the general population. Methods: All patients (n = 63,998) aged ≥ 50 years who received a diagnosis of gastric cancer and underwent curative gastrectomy between 2007 and 2012 and a noncancer control population (n = 203,276), matched by age and sex, were identified from the Korean National Health Insurance Services and traced until 2017. Hazard ratios and 95% confidence intervals for dementia were calculated with a Cox regression analysis. Results: Gastric cancer patients who received a gastrectomy showed an increased risk of AD [adjusted hazard ration (aHR) 1.08, 95% confidence interval (CI) 1.03–1.14], and the risk was especially marked for those who received a total gastrectomy (aHR 1.39, 95% CI 1.25–1.54). Gastric cancer survivors showed a decreased risk for VaD (aHR 0.85; 95% CI 0.73–0.98) regardless of operation type. Those who received continual vitamin B<subscript>12</subscript> supplementation after a total gastrectomy were less likely than controls to develop AD (aHR 0.71; 95% CI 0.54–0.92). Conclusions: Compared with controls, gastric cancer patients who received a total gastrectomy had an increased incidence of AD and a decreased risk of VaD. Our results suggest that vitamin B<subscript>12</subscript> deficiency might play a role in the development of AD and highlight the need for vitamin B<subscript>12</subscript> supplementation after total gastrectomy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10689265
- Volume :
- 26
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Annals of Surgical Oncology: An Oncology Journal for Surgeons
- Publication Type :
- Academic Journal
- Accession number :
- 139744481
- Full Text :
- https://doi.org/10.1245/s10434-019-07913-8