Palladium(II) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.

Authors :: Oliveira, Carolina G.
Romero-Canelón, Isolda
Silva, Monize M.
Coverdale, James P. C.
Maia, Pedro Ivo S.
Batista, Alzir A.
Castelli, Silvia
Desideri, Alessandro
Sadler, Peter J.
Deflon, Victor M.
Source :: Dalton Transactions: An International Journal of Inorganic Chemistry; 11/28/2019, Vol. 48 Issue 44, p16509-16517, 9p
Publication Year :: 2019
Abstract: New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human ovarian cancer cells, which is dependent on substituent groups of the thiosemicarbazone ligands. Cellular accumulation and distribution studies confirmed that palladium enters the cell nucleus. DNA and topoisomerase IB studies show that one complex is a potent TopIB inhibitor, with selectivity for cancer versus normal cells. [ABSTRACT FROM AUTHOR]

Subjects :: THIOSEMICARBAZONES
PALLADIUM
CELL nuclei
OVARIAN cancer
CANCER cells
LIGANDS (Chemistry)

Language :: English
ISSN :: 14779226
Volume :: 48
Issue :: 44
Database :: Complementary Index
Journal :: Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :: Academic Journal
Accession number :: 139626080
Full Text :: https://doi.org/10.1039/c9dt02570g

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