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Effect of Ruellia tuberosa L. on aorta endothelial damage‐associated factors in high‐fat diet and streptozotocin‐induced type 2 diabetic rats.

Authors :
Ko, Chih‐Yuan
Lin, Ru‐Hai
Lo, Yangming Martin
Chang, Wen‐Chang
Huang, Da‐Wei
Wu, James Swi‐Bea
Chang, Yu‐Fang
Huang, Wen‐Chung
Shen, Szu‐Chuan
Source :
Food Science & Nutrition; Nov2019, Vol. 7 Issue 11, p3742-3750, 9p
Publication Year :
2019

Abstract

Hyperglycemia plays crucial roles in vascular disease development, including macrovascular and microvascular diseases from diabetes mellitus (DM). Our previous study demonstrated that Ruellia tuberosa L. (RTL) aqueous and ethanol extracts alleviate hyperglycemia and inhibit insulin resistance in diabetic rats. This study investigated the protective effect of RTL ethanol extract against aorta dysfunction in high‐fat diet (HFD) and streptozotocin (STZ)‐induced type 2 DM (T2DM) rats. Results showed that RTL ethanol extract (100 and 400 mg/kg BW/day) ameliorated serum lipid profiles, including triglyceride, free fatty acid, low‐density lipoprotein cholesterol, very low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol levels. It also significantly reduced the level of serum cytokines such as tumor necrosis factor‐α (TNF‐α) and interleukin‐6 in T2DM rats. Additionally, RTL extract decreased endothelin‐1 and endothelial nitric oxide contents, reduced the level of cell adhesion factors, including monocyte chemoattractant protein‐1 and cell adhesion factor vascular cell adhesion molecule‐1, while decreasing content of damage factors, namely tissue factor and von Willebrand factor in aortic tissues of diabetic rats. Equally noteworthy is that RTL extract enhanced the activity of aorta antioxidative enzymes, including superoxidase dismutase and catalase in diabetic rats, suggesting that RTL ethanol extract may ameliorate aorta dysfunction via enhancing aortic antioxidative enzyme activity, which subsequently suppresses aorta endothelial damage‐associated factors in HFD with STZ‐induced T2DM rats. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20487177
Volume :
7
Issue :
11
Database :
Complementary Index
Journal :
Food Science & Nutrition
Publication Type :
Academic Journal
Accession number :
139622857
Full Text :
https://doi.org/10.1002/fsn3.1233