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Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study.
- Source :
- Cancer Management & Research; Oct2019, Vol. 11, p8877-8883, 7p
- Publication Year :
- 2019
-
Abstract
- Purpose: To fully elucidate the relationship of serum fibrinogen and the prognosis of esophageal squamous cell carcinoma. Methods: The concentrations of serum fibrinogen were measured by the Clauss method in a total of 1331 operable esophageal squamous cell carcinoma (ESCC) patients from the past 3 years. The correlation of serum fibrinogen concentration and patient outcome and clinical pathological factors was tested. Results: Hyperfibrinogenemia was significantly correlated with advanced pathological T stage and TNM stage. Serum fibrinogen was determined as a worse independent survival predictor in ESCC by survival analysis. The hazard ratio was 1.672 (95% confidence interval [CI] 1.043–2.681). A subgroup analysis further elucidated a significant correlation between hyperfibrinogenemia and younger age (P=0.011), being female (P=0.002), not having a history of smoking (p<0.001) or alcohol consumption (p<0.001), pathological N0 stage (P=0.002), and early pathological TNM stage (I-II) (P=0.004). Conclusion: This research showed that preoperative serum fibrinogen is an independent prognostic factor for survival in ESCC, especially for the early pathological TNM stage (I-II) and N0 patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- FIBRINOGEN
SERUM
SQUAMOUS cell carcinoma
Subjects
Details
- Language :
- English
- ISSN :
- 11791322
- Volume :
- 11
- Database :
- Complementary Index
- Journal :
- Cancer Management & Research
- Publication Type :
- Academic Journal
- Accession number :
- 139509441
- Full Text :
- https://doi.org/10.2147/CMAR.S212192