Sex‐specific plasma metabolome signatures in major depressive disorder.

Major depressive disorder (MDD) is a highly prevalent mental disorder with obvious sex differences.[1] Numerous metabolomics studies have investigated the differential expressed metabolic signatures in MDD; however, few studies have investigated the sex differences at the large-scale molecular level other than transcriptome.[[2]] Here, we investigated the sex differences of plasma metabolome signatures in antidepressant-naive patients with MDD. GLO:82I/01nov19:pcn12925-sup-0001-FigureS1.jpg PHOTO (COLOR): Figure S1 Metabolomic analysis of plasma samples from male and female major depressive disorder (MDD) patients versus healthy controls (HC). GLO:82I/01nov19:pcn12925-sup-0004-FigureS4.jpg PHOTO (COLOR): Figure S4 Weighted gene correlation network analysis of metabolic profiles of patients with major depressive disorder (MDD). For the rank-rank hypergeometric overlap test plot, a hot spot in the bottom left corner indicates overlap in metabolites upregulated in male and female patients. gl. [Extracted from the article]