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Longitudinal Changes in Insulin Resistance in Normal Weight, Overweight and Obese Individuals.
- Source :
- Journal of Clinical Medicine; May2019, Vol. 8 Issue 5, p623, 1p
- Publication Year :
- 2019
-
Abstract
- Background: Large cohort longitudinal studies have almost unanimously concluded that metabolic health in obesity is a transient phenomenon, diminishing in older age. We aimed to assess the fate of insulin sensitivity per se over time in overweight and obese individuals. Methods: Individuals studied using the hyperinsulinaemic-euglycaemic clamp at the Garvan Institute of Medical Research from 2008 to 2010 (n = 99) were retrospectively grouped into Lean (body mass index (BMI) < 25 kg/m<superscript>2</superscript>) or overweight/obese (BMI ≥ 25 kg/m<superscript>2</superscript>), with the latter further divided into insulin-sensitive (Ob<subscript>Sen</subscript>) or insulin-resistant (Ob<subscript>Res</subscript>), based on median clamp M-value (M/I, separate cut-offs for men and women). Fifty-seven individuals participated in a follow-up study after 5.4 ± 0.1 years. Hyperinsulinaemic-euglycaemic clamp, dual-energy X-ray absorptiometry and circulating cardiovascular markers were measured again at follow-up, using the same protocols used at baseline. Liver fat was measured using computed tomography at baseline and proton magnetic resonance spectroscopy at follow-up with established cut-offs applied for defining fatty liver. Results: In the whole cohort, M/I did not change over time (p = 0.40); it remained significantly higher at follow-up in Ob<subscript>Sen</subscript> compared with Ob<subscript>Res</subscript> (p = 0.02), and was not different between Ob<subscript>Sen</subscript> and Lean (p = 0.41). While BMI did not change over time (p = 0.24), android and visceral fat increased significantly in this cohort (p<subscript>time</subscript> ≤ 0.0013), driven by Ob<subscript>Res</subscript> (p = 0.0087 and p = 0.0001, respectively). Similarly, systolic blood pressure increased significantly over time (p<subscript>time</subscript> = 0.0003) driven by Ob<subscript>Res</subscript> (p = 0.0039). The best correlate of follow-up M/I was baseline M/I (Spearman's r = 0.76, p = 1.1 × 10<superscript>−7</superscript>). Conclusions: The similarity in insulin sensitivity between the Ob<subscript>Sen</subscript> and the Lean groups at baseline persisted over time. Insulin resistance in overweight and obese individuals predisposed to further metabolic deterioration over time. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 8
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 139329861
- Full Text :
- https://doi.org/10.3390/jcm8050623