Back to Search
Start Over
Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure.
- Source :
- Thorax; Nov2019, Vol. 74 Issue 11, p1099-1101, 3p
- Publication Year :
- 2019
-
Abstract
- Muscle mitochondrial dysfunction is implicated in intensive care unit-acquired weakness, but there is no serum biomarker of muscle mitochondrial function for critical illness survivors. Higher serum growth differentiation factor-15 (GDF-15) is a biomarker of inherited mitochondrial myopathy disease and is associated with mortality in several age-related diseases. Among 142 older (age ≥ 65 years) survivors of acute respiratory failure, we found that higher serum GDF-15 measured during the week prior to hospital discharge was cross-sectionally associated with weaker diaphragm, limb and hand-grip strength, and longitudinally associated with lower rates of functional recovery over 6 months, independent of age, sex, pre-existing disability, comorbidity, frailty, Acute Physiology and Chronic Health Evaluation II scores and concurrent interleukin-6 levels. [ABSTRACT FROM AUTHOR]
- Subjects :
- ADULT respiratory distress syndrome
APACHE (Disease classification system)
Subjects
Details
- Language :
- English
- ISSN :
- 00406376
- Volume :
- 74
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Thorax
- Publication Type :
- Academic Journal
- Accession number :
- 139146613
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2019-213621